Carboxylic acids and derivatives
Medchemexpress LLC Peg3-o-ch2cooh (protac linker 8) | 51951-05-4 | ≥95.0% | 50 MG
PEG3-O-CH2COOH (PROTAC Linker 8) is a PEG-based PROTAC linker primarily used in the synthesis of SNIPERs. It can also be utilized as PROTAC linker (Compound 15b) in the synthesis of SNIPER(ER)s. These SNIPERs are designed to recruit inhibitor of apoptosis protein (IAP) ubiquitin ligases for the specific degradation of targeted proteins. This product is intended for research use only and is not for patient treatment.
- PEG-based PROTAC linker
- Used in the synthesis of SNIPERs
- Utilized as PROTAC linker (Compound 15b) in the synthesis of SNIPER(ER)s
- Recruits inhibitor of apoptosis protein (IAP) ubiquitin ligases
- Facilitates specific degradation of targeted proteins
- For research use only
Medchemexpress LLC COR659 | 544450-68-2 | 99.9% | 337.82 | 50 MG
COR659 is a potent and effective GABAB positive allosteric modulator (PAM). It suppresses alcohol and chocolate self-administration in rats. It appears to act through a composite mechanism, including positive allosteric modulation of the GABAB receptor and an action at the cannabinoid CB1 receptor.
- Potent and effective GABAB positive allosteric modulator (PAM).
- Suppresses alcohol and chocolate self-administration in rats.
- Effective in reducing lever-responses for sucrose and chocolate solutions in rats.
- In vivo studies indicate no effect on lever-responding for regular food pellets in food-deprived Wistar rats.
- Demonstrates a dose-dependent reduction in lever-responses for alcohol in rats.
Medchemexpress LLC Fmoc-NH-PEG6-CH2COOH | 437655-96-4 | 99.4% | 561.62 | C29H39NO10 | 25 MG
Fmoc-NH-PEG6-CH2COOH is an Fmoc-protected PEG6 linker with a terminal carboxylic acid used as a hydrophilic spacer for conjugation chemistry. It is commonly used in antibody-drug conjugate (ADC) and PROTAC synthesis to provide a soluble linker and a protected amine for further derivatization.
- Cleavable PEG-based linker suitable for ADC and PROTAC synthesis.
- Provides an Fmoc-protected amine and a terminal carboxylic acid for conjugation.
- Molecular weight 561.62 and formula C29H39NO10.
- Purity 99.37% as reported by the supplier.
- Soluble in DMSO at 100 mg/mL; may require sonication.
- Storage: pure form -20 °C (3 years) or 4 °C (2 years); in solvent -80 °C (6 months) or -20 °C (1 month).
- Available in small lab pack sizes, including 25 mg.
Medchemexpress LLC L-Aspartic acid, N-(phosphonoacetyl)-, trisodium salt | 70962-66-2 | 98.0% | 321.06 | 10 MG
Sparfosic acid trisodium is a DNA antimetabolite agent and a potent inhibitor of aspartate transcarbamoyl transferase, which catalyzes the second step of de novo pyrimidine biosynthesis. It synergistically enhances the cytotoxicity of a combination of 5-fluorouracil (5-FU) and interferon-alpha (IFN) against human colon cancer cell lines. It is for research use only and not sold to patients.
- DNA antimetabolite agent
- Potent inhibitor of aspartate transcarbamoyl transferase
- Synergistically enhances the cytotoxicity of 5-FU and IFN against human colon cancer cell lines
- Treatment with 490 mg/kg in mice bearing B16 melanoma increased life-span by 77% to 86%
- Lewis lung carcinoma is highly sensitive, with treatment leading to a cure in 50% of mice
Medchemexpress LLC Potassium phosphate tribasic | 7778-53-2 | MFCD00036295 | 98.7% | 212.27 g/mol | K3O4P | 1g
Tripotassium phosphate is a kind of biological materials or organic compounds that are widely used in life science research[1]
Selleck Chemical LLC Oxeladin Citrate S4402-25mg
Oxeladin citrate (OL) a cough suppressant is a highly potent and effective drug applied in the treatment of all types of cough of various etiologies
Selleck Chemical LLC Oxacillin sodium monohydrate S2563-50mg
Oxacillin sodium monohydrate (Methicillin) is an antibacterial agent and is a narrow spectrum beta-lactam antibiotic of the penicillin class
Medchemexpress LLC (E/Z)-Zotiraciclib hydrochloride | 1321626-25-8 | C23H25ClN4O | 5 MG
(E/Z)-Zotiraciclib ((E/Z)-TG02) is an orally active inhibitor of CDK2, JAK2, and FLT3 with IC50s of 13, 73, and 56 nM, respectively. It effectively inhibits the proliferation of cancer cells, making it suitable for cancer research.
- Orally active inhibitor of CDK2, JAK2, and FLT3
- Inhibits proliferation of cancer cells
- Useful for cancer research
- Potently inhibits the CDK2 biomarker pRb
TARGETMOL CHEMICALS INC SPD-473 citrate 1MG
Also available in 5 mg, 10 mg, 25 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. SPD-473 citrate (BTS 74398 citrate) is a dopamine reuptake inhibitor, a norepinephrine transporter protein (NET) inhibitor, and a 5-hydroxytryptamine reuptake inhibitor, and is used in the study of neurological disorders and endocrine and metabolic diseases. Purity 99.37%
![eMolecules 5785-44-4 | Calcium citrate tribasic tetrahydrate | Oakwood Chemicals570.492 | C12H18Ca3O18 | 98.000 | O.O.O.O.[Ca++].[Ca++].[Ca++].OC(CC([O-])=O)(CC([O-])=O)C([O-])=O.OC(CC([O-])=O)(CC([O-])=O)C([O-])=O | 5g | 480154817](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502151478.JPG-250.jpg)
eMolecules 5785-44-4 | Calcium citrate tribasic tetrahydrate | Oakwood Chemicals570.492 | C12H18Ca3O18 | 98.000 | O.O.O.O.[Ca++].[Ca++].[Ca++].OC(CC([O-])=O)(CC([O-])=O)C([O-])=O.OC(CC([O-])=O)(CC([O-])=O)C([O-])=O | 5g | 480154817
Calcium citrate tribasic tetrahydrate | Oakwood Chemicals | 5785-44-4570.492 | C12H18Ca3O18 | 98.000 | O.O.O.O.[Ca++].[Ca++].[Ca++].OC(CC([O-])=O)(CC([O-])=O)C([O-])=O.OC(CC([O-])=O)(CC([O-])=O)C([O-])=O | 5g | 480154817
Medchemexpress LLC PF-543 Citrate | 1415562-83-2 | C33H39NO11S | 1 ML
PF-543 Citrate (Sphingosine Kinase 1 Inhibitor II Citrate) is a potent, selective, reversible, and sphingosine-competitive SPHK1 inhibitor with an IC50 of 2 nM and a Ki of 3.6 nM. It demonstrates over 100-fold selectivity for SPHK1 over SPHK2. PF-543 Citrate is an effective inhibitor of sphingosine 1-phosphate (S1P) formation in whole blood with an IC50 of 26.7 nM. It is known to induce apoptosis, necrosis, and autophagy.
- Potent, selective, reversible, and sphingosine-competitive SPHK1 inhibitor
- IC50 of 2 nM and Ki of 3.6 nM for SPHK1
- Over 100-fold selectivity for SPHK1 over SPHK2
- Effective inhibitor of sphingosine 1-phosphate (S1P) formation in whole blood with an IC50 of 26.7 nM
- Induces apoptosis, necrosis, and autophagy
eMolecules 1021868-83-6 | Medchem Express | ARL67156 (trisodium) | 1mg | 527574555 | HY-103265 | 785.055 | C15H21Br2N5Na3O12P3
Ambeed | 4-Fluoro-3-hydroxybenzaldehyde | 250mg | 572969521 | A543929 | 103438-85-3 | MFCD11110190 | 140.113 | C7H5FO2
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Medchemexpress LLC Toremifene (Citrate) | 89778-27-8 | 99.9% | C32H36ClNO8 | 1 ML
Toremifene citrate (Z-Toremifene citrate) is a second-generation selective estrogen-receptor modulator (SERM) developed for the prevention of osteoporosis and other adverse effects from Androgen Deprivation Therapy (ADT) in prostate cancer. It also potently inhibits infectious EBOV Zaire and Marburg (MARV) with IC50 values of 0.07 μM and 2.6 μM, respectively.
- Second-generation selective estrogen-receptor modulator (SERM).
- Developed for the prevention of osteoporosis.
- Potently inhibits infectious EBOV Zaire and Marburg (MARV).
- Used in development for the prevention of adverse effects from ADT with prostate cancer.
- Inhibits growth of Ac-1 cells in vitro.
- Stable under recommended storage conditions.
- Soluble in DMSO (≥ 100 mg/mL).
eMolecules 1002359-83-2 | tert-butyl (3R)-3-(hydrazinecarbonyl)piperidine-1-carboxylate | MFCD11111950 | 1g
Ambeed | N-(22-Dimethoxyethyl)-3-nitropyridin-2-amine | 1g | 572948211 | A364367 | 1003947-06-5 | MFCD12068362 | 227.220 | C9H13N3O4
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